{"product_id":"retevmo-selpercatinib-80mg-120-capsules","title":"Retevmo (Selpercatinib) 80mg 120 Capsules","description":"\u003cdiv class=\"flex-shrink-0 flex flex-col relative items-end\"\u003e\r\n\u003cdiv\u003e\r\n\u003cdiv class=\"pt-0\"\u003e\r\n\u003cdiv class=\"gizmo-bot-avatar flex h-8 w-8 items-center justify-center overflow-hidden rounded-full\"\u003e\r\n\u003cdiv class=\"relative p-1 rounded-sm flex items-center justify-center bg-token-main-surface-primary text-token-text-primary h-8 w-8\"\u003e\u003cspan style=\"font-size: 18px; color: #333333; font-family: 'Open Sans', 'Helvetica Neue', Helvetica, Arial, sans-serif; font-weight: 600;\"\u003eRetevmo (Selpercatinib) - Comprehensive Product Description\u003c\/span\u003e\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003cdiv class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\"\u003e\r\n\u003cdiv class=\"flex-col gap-1 md:gap-3\"\u003e\r\n\u003cdiv class=\"flex max-w-full flex-col flex-grow\"\u003e\r\n\u003cdiv class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words [.text-message+\u0026amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"3bf195a6-32d9-4efb-b5a8-08d2eb69d967\" data-message-model-slug=\"gpt-4o\"\u003e\r\n\u003cdiv class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\"\u003e\r\n\u003cdiv class=\"markdown prose w-full break-words dark:prose-invert dark\"\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eRetevmo\u003c\/strong\u003e is a prescription medication containing the active ingredient \u003cstrong\u003eSelpercatinib\u003c\/strong\u003e, a targeted cancer therapy used to treat certain types of cancers driven by \u003cstrong\u003eRET gene mutations or fusions\u003c\/strong\u003e. It is specifically indicated for the treatment of patients with \u003cstrong\u003enon-small cell lung cancer (NSCLC)\u003c\/strong\u003e, \u003cstrong\u003emedullary thyroid cancer (MTC)\u003c\/strong\u003e, and \u003cstrong\u003eother types of thyroid cancer\u003c\/strong\u003e that have RET alterations. Retevmo works by inhibiting the activity of the RET protein, which plays a crucial role in the growth and survival of cancer cells.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Class\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Class\u003c\/strong\u003e: Kinase Inhibitor, Targeted Therapy\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCategories\u003c\/strong\u003e: Cancer Treatment, Precision Medicine, Targeted Cancer Therapy\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eActive Ingredient Name\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eActive Ingredient\u003c\/strong\u003e: \u003cstrong\u003eSelpercatinib\u003c\/strong\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003ePopular and Other Names\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eBrand Name\u003c\/strong\u003e: Retevmo\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eGeneric Name\u003c\/strong\u003e: Selpercatinib\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eOther Names\u003c\/strong\u003e: RET Inhibitor, Selpercatinib Capsules\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eMode of Action\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eRetevmo targets and inhibits the activity of the \u003cstrong\u003eRET (Rearranged during Transfection) kinase\u003c\/strong\u003e, a protein that is abnormally activated in cancers with \u003cstrong\u003eRET gene mutations or fusions\u003c\/strong\u003e. By blocking the RET protein’s activity, Retevmo helps:\u003c\/span\u003e\u003c\/p\u003e\r\n\u003col\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eInhibit Tumor Growth\u003c\/strong\u003e: Prevents cancer cells from proliferating, thereby reducing tumor size and slowing disease progression.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eInduce Cancer Cell Death\u003c\/strong\u003e: Triggers mechanisms within the cancer cells that lead to apoptosis (programmed cell death), effectively eliminating some cancer cells.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eMinimize Metastasis\u003c\/strong\u003e: Helps reduce the spread of cancer to other parts of the body, improving patient outcomes.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eThis targeted approach ensures that the therapy is more specific to cancer cells with RET alterations, while having a lesser effect on normal, healthy cells.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eHow to Use It\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eRetevmo is taken orally in capsule form, typically under the supervision of an oncologist. It is important to follow the prescribed dosing schedule for optimal results.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eRecommended Dosage\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\n\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAdults and Pediatric Patients (≥12 Years)\u003c\/strong\u003e:\u003c\/span\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eBody Weight ≥50 kg\u003c\/strong\u003e: \u003cstrong\u003e160 mg twice daily\u003c\/strong\u003e.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eBody Weight \u0026lt;50 kg\u003c\/strong\u003e: \u003cstrong\u003e120 mg twice daily\u003c\/strong\u003e.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDuration\u003c\/strong\u003e: Treatment continues until disease progression or unacceptable toxicity occurs. Always follow your oncologist's recommendations for dosing and duration.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003col\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eTake with or without Food\u003c\/strong\u003e: Swallow the capsules whole with water. Do not crush, chew, or open the capsules.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eConsistent Timing\u003c\/strong\u003e: Take the medication at the same time each day to maintain stable blood levels.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eMissed Dose\u003c\/strong\u003e: If a dose is missed by more than 6 hours, skip the missed dose and resume the regular schedule. Do not take an extra dose to make up for the missed one.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCautions\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eLiver Monitoring\u003c\/strong\u003e: Retevmo may cause liver toxicity. Regular monitoring of liver function tests is recommended.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eBlood Pressure Monitoring\u003c\/strong\u003e: Patients should have their blood pressure monitored regularly, as hypertension may occur.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAvoid in Pregnancy\u003c\/strong\u003e: Retevmo can harm an unborn baby. It should not be used during pregnancy, and effective contraception should be used during treatment and for at least 1 week after the last dose.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Interactions\u003c\/strong\u003e: Avoid taking Retevmo with certain medications that can affect liver enzymes, as they may alter the effectiveness of the treatment. Inform your doctor about all medications you are taking.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eManaging Side Effects\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCommon Side Effects\u003c\/strong\u003e: Include dry mouth, diarrhea, high blood pressure, fatigue, nausea, and constipation.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSerious Side Effects\u003c\/strong\u003e: May include liver problems, severe hypertension, bleeding, allergic reactions, and heart rhythm abnormalities (QT prolongation). If you experience any serious symptoms, contact your healthcare provider immediately.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eManagement Tips\u003c\/strong\u003e: Stay hydrated and eat small, frequent meals to manage nausea. Monitor blood pressure regularly and follow dietary recommendations if advised by your healthcare team.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eGuidelines\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003col\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eRegular Monitoring\u003c\/strong\u003e: Follow your healthcare provider’s instructions for regular monitoring of blood tests, liver function, and blood pressure.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eReport Symptoms\u003c\/strong\u003e: Inform your healthcare provider of any new or worsening symptoms, including unexplained bleeding, chest pain, or swelling.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eUse Effective Birth Control\u003c\/strong\u003e: Use contraception during treatment and for 1 week after the last dose if you are of childbearing potential.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eFrequently Asked Questions (FAQs)\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003col\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat is Retevmo used for?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eRetevmo is used to treat certain types of cancers with RET gene mutations or fusions, including non-small cell lung cancer, medullary thyroid cancer, and other thyroid cancers.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eHow does Retevmo work?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eRetevmo inhibits the RET protein's activity, which is involved in cancer cell growth and survival. By blocking this protein, it helps reduce tumor growth and spread.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan Retevmo be used as a first-line treatment?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eYes, Retevmo can be used as a first-line treatment for patients with RET-positive cancers.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eHow long should I take Retevmo?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eTreatment with Retevmo typically continues until the cancer progresses or significant side effects occur. Your oncologist will determine the duration based on your response.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat should I do if I miss a dose of Retevmo?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eIf you miss a dose by more than 6 hours, skip it and resume your regular dosing schedule. Do not take a double dose to make up for the missed one.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAre there any dietary restrictions while taking Retevmo?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eThere are no specific dietary restrictions, but avoid grapefruit and grapefruit juice, as they may interact with the medication.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan I take Retevmo if I’m pregnant?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eNo, Retevmo can harm an unborn baby. It should not be used during pregnancy, and effective contraception should be used during treatment.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDoes Retevmo cause high blood pressure?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eYes, high blood pressure is a common side effect. Regular monitoring and management by your healthcare provider are recommended.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eQuick Links\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/uspl.lilly.com\/retevmo\/retevmo.html#pi\"\u003eRetevmo Product Information\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8599646\/\"\u003eRET Inhibitors in Cancer Treatment\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/targeted-therapies\"\u003eManaging Side Effects of Targeted Cancer Therapies\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7328108\/\" target=\"_new\" rel=\"noopener\"\u003eUnderstanding RET Gene Mutations\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/selpercatinib-oral-route\/proper-use\/drg-20512415\" target=\"_new\" rel=\"noopener\"\u003eRetevmo Dosage Guidelines\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e\r\n\u003c\/div\u003e","brand":"EZ Chemist","offers":[{"title":"Default Title","offer_id":51735708270875,"sku":"Retevmo (Selpercatinib) 80mg x 120 Capsules","price":6744.6,"currency_code":"USD","in_stock":true}],"url":"https:\/\/ezchemist.com\/products\/retevmo-selpercatinib-80mg-120-capsules","provider":"EZ Chemist","version":"1.0","type":"link"}