{"product_id":"resof-total-sofosbuvir-velpatasvir-400-100mg-28-tablets","title":"Resof Total (Sofosbuvir \u0026 Velpatasvir) 400\/100mg 28 Tablets","description":"\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eResof Total (Sofosbuvir and Velpatasvir Combination Tablets) - Medicine Description\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSofosbuvir and Velpatasvir Combination Tablets\u003c\/strong\u003e are used in the treatment of chronic \u003cstrong\u003eHepatitis C virus (HCV)\u003c\/strong\u003e infection in adults. Marketed under the brand name \u003cstrong\u003eEpclusa\u003c\/strong\u003e, this combination drug provides a comprehensive treatment option for all genotypes of the Hepatitis C virus, making it a versatile choice for patients with or without cirrhosis. The combination includes \u003cstrong\u003eSofosbuvir\u003c\/strong\u003e and \u003cstrong\u003eVelpatasvir\u003c\/strong\u003e, two potent direct-acting antivirals that work together to stop the virus from replicating and promote viral clearance from the body.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch4\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Class\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h4\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Class\u003c\/strong\u003e: Direct-acting Antivirals (DAA)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCategories\u003c\/strong\u003e: Antiviral Agent, Hepatitis C Treatment\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch4\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eActive Ingredient Name\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h4\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eActive Ingredients\u003c\/strong\u003e: Sofosbuvir (400 mg) and Velpatasvir (100 mg)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch4\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003ePopular and Other Names\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h4\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eBrand Name\u003c\/strong\u003e: Epclusa\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eGeneric Name\u003c\/strong\u003e: Sofosbuvir and Velpatasvir\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eOther Names\u003c\/strong\u003e: Sofosbuvir-Velpatasvir Tablets\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eMode of Action:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eThe combination of Sofosbuvir and Velpatasvir works synergistically to inhibit the replication of the Hepatitis C virus:\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSofosbuvir\u003c\/strong\u003e is a \u003cstrong\u003enucleotide analog inhibitor\u003c\/strong\u003e of the NS5B RNA-dependent RNA polymerase enzyme, which is critical for viral RNA replication.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eVelpatasvir\u003c\/strong\u003e is an \u003cstrong\u003eNS5A inhibitor\u003c\/strong\u003e that disrupts the assembly and replication of the virus. Together, they block the viral lifecycle at multiple stages, preventing the virus from multiplying and reducing the viral load in the body.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eHow to Use It:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eSofosbuvir and Velpatasvir combination tablets are taken orally, once daily, with or without food. The tablets should be swallowed whole without chewing, crushing, or breaking them.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eRecommended Dosage:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eStandard Dosage\u003c\/strong\u003e: One tablet (Sofosbuvir 400 mg + Velpatasvir 100 mg) once daily for \u003cstrong\u003e12 weeks\u003c\/strong\u003e.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSpecial Considerations\u003c\/strong\u003e: For patients with decompensated cirrhosis, the combination is usually administered with \u003cstrong\u003eribavirin\u003c\/strong\u003e for 12 weeks. Dosage adjustments are based on patient condition and treatment response.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eDirections:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eTake the medication at the same time each day to maintain consistent levels in the blood.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eDo not skip doses or discontinue use without consulting your healthcare provider, as this may lead to drug resistance or treatment failure.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eIf you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose and resume your regular schedule.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eCautions:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003ePregnancy and Breastfeeding\u003c\/strong\u003e: Not recommended for use during pregnancy, particularly if combined with ribavirin. Women of childbearing age should use effective contraception during and after treatment.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Interactions\u003c\/strong\u003e: Sofosbuvir and Velpatasvir can interact with other medications, such as \u003cstrong\u003eantacids, St. John’s Wort, rifampin\u003c\/strong\u003e, and certain anticonvulsants. Always inform your healthcare provider about all medications and supplements you are taking.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eLiver Function\u003c\/strong\u003e: Regular liver function tests are recommended to monitor the effectiveness of the treatment.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDo Not Use With Amiodarone\u003c\/strong\u003e: The combination can cause life-threatening bradycardia when used with amiodarone.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eManaging Side Effects:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCommon Side Effects\u003c\/strong\u003e: Headache, fatigue, nausea, and insomnia.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSerious Side Effects\u003c\/strong\u003e: Symptoms of liver problems (yellowing of the skin or eyes, dark urine), chest pain, or shortness of breath. Seek immediate medical attention if these symptoms occur.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eManagement Tips\u003c\/strong\u003e: For mild side effects, drink plenty of water, get adequate rest, and take medications like acetaminophen (as advised by your healthcare provider). If side effects persist, consult your doctor.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eGuidelines:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eContinue taking Sofosbuvir and Velpatasvir for the full duration of the treatment course, even if you start feeling better.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eAvoid alcohol, as it can increase the risk of liver damage.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eRegular blood tests are necessary to monitor liver function and treatment efficacy.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eDo not take this medication along with other drugs for Hepatitis C unless directed by a healthcare provider.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eFrequently Asked Questions (FAQs)\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003col\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat is Sofosbuvir and Velpatasvir used for?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eThis combination is used for the treatment of chronic Hepatitis C infection across all genotypes (genotypes 1 to 6). It is effective for patients both with and without cirrhosis.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan Sofosbuvir and Velpatasvir cure Hepatitis C?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eYes, when taken as directed, this combination can achieve a sustained virologic response (SVR), which is considered a \"functional cure\" for Hepatitis C.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat are the common side effects of Sofosbuvir and Velpatasvir?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eThe most common side effects include headache, fatigue, and nausea. These symptoms are usually mild and improve over time.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eIs it safe to use Sofosbuvir and Velpatasvir during pregnancy?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eIt is not recommended during pregnancy, especially when used with ribavirin. Women should use effective contraception during and for 6 months after treatment.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan I drink alcohol while taking Sofosbuvir and Velpatasvir?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eAvoid alcohol during treatment, as it can increase the risk of liver damage and affect treatment outcomes.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eHow long is the treatment duration?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eThe standard treatment duration is 12 weeks, but this may vary depending on the presence of cirrhosis or other health conditions.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat should I do if I miss a dose?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eIf you miss a dose, take it as soon as you remember, but do not double the next dose to make up for the missed one.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan I take antacids with Sofosbuvir and Velpatasvir?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eAvoid taking antacids within 4 hours of taking Sofosbuvir and Velpatasvir, as they can reduce the absorption and effectiveness of the medication.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eQuick Links\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca target=\"_new\" rel=\"noopener\"\u003eUnderstanding Sofosbuvir and Velpatasvir Mechanism\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/sofosbuvir-velpatasvir-oral-route\/dosage\/drg-20374643\" target=\"_new\" rel=\"noopener\"\u003eDosage Recommendations for Hepatitis C Treatment\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca target=\"_new\" rel=\"noopener\"\u003eManaging Side Effects of Hepatitis C Medications\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca target=\"_new\" rel=\"noopener\"\u003eDrug Interactions with Sofosbuvir and Velpatasvir\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5500068\/\" target=\"_new\" rel=\"noopener\"\u003eSofosbuvir and Velpatasvir in Pregnancy\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e","brand":"EZ Chemist","offers":[{"title":"Default Title","offer_id":51736348819739,"sku":"Resof (Sofosbuvir \u0026 Velpatasvir) 400\/100mg","price":468.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0992\/3303\/8619\/files\/journalk_4.png?v=1770433906","url":"https:\/\/ezchemist.com\/products\/resof-total-sofosbuvir-velpatasvir-400-100mg-28-tablets","provider":"EZ Chemist","version":"1.0","type":"link"}