{"product_id":"ledipasvir-and-sofosbuvir-harvoni-90-400mg-28-tablets","title":"Ledipasvir and Sofosbuvir (Harvoni) 90\/400mg 28 Tablets","description":"\u003cul\u003e\r\n\u003cli\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eSofosbuvir and Ledipasvir Combination Tablets - Medicine Description\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSofosbuvir and Ledipasvir Combination Tablets\u003c\/strong\u003e are a potent antiviral treatment for chronic \u003cstrong\u003eHepatitis C virus (HCV)\u003c\/strong\u003e infection in adults. This combination is highly effective for the treatment of genotypes 1, 4, 5, and 6, offering a cure for a majority of patients without the need for additional antiviral medications. Marketed under the brand name \u003cstrong\u003eHarvoni\u003c\/strong\u003e, this fixed-dose combination provides a convenient, once-daily regimen that simplifies Hepatitis C treatment.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch4\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Class\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h4\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Class\u003c\/strong\u003e: Direct-acting Antivirals (DAA)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCategories\u003c\/strong\u003e: Antiviral Agent, Hepatitis C Treatment\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch4\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eActive Ingredient Name\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h4\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eActive Ingredients\u003c\/strong\u003e: Sofosbuvir (400 mg) and Ledipasvir (90 mg)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003ch4\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003ePopular and Other Names\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h4\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eBrand Name\u003c\/strong\u003e: Harvoni\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eGeneric Name\u003c\/strong\u003e: Sofosbuvir and Ledipasvir\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eOther Names\u003c\/strong\u003e: Sofosbuvir-Ledipasvir Tablets, Ledifos, Resof L\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eMode of Action:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eThe combination of Sofosbuvir and Ledipasvir works by targeting different stages of the Hepatitis C virus replication cycle:\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSofosbuvir\u003c\/strong\u003e is a \u003cstrong\u003enucleotide analog inhibitor\u003c\/strong\u003e of the \u003cstrong\u003eNS5B RNA-dependent RNA polymerase\u003c\/strong\u003e enzyme, blocking the replication of viral RNA.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eLedipasvir\u003c\/strong\u003e is an \u003cstrong\u003eNS5A inhibitor\u003c\/strong\u003e, which interferes with the assembly and replication of the virus. When used together, these medications suppress the replication of the virus, reducing the viral load and promoting viral clearance.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eHow to Use It:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eSofosbuvir and Ledipasvir are taken orally as a single, fixed-dose tablet once daily. The medication can be taken with or without food. Swallow the tablet whole; do not chew, crush, or break it.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eRecommended Dosage:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eStandard Dosage\u003c\/strong\u003e: One tablet (400 mg Sofosbuvir + 90 mg Ledipasvir) once daily for \u003cstrong\u003e12 weeks\u003c\/strong\u003e.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eFor Patients with Cirrhosis\u003c\/strong\u003e: The duration may extend up to 24 weeks, depending on the severity of cirrhosis and prior treatment history.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCo-Infection with HIV\u003c\/strong\u003e: Same dosage, but close monitoring is necessary due to potential drug interactions.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eAlways consult your healthcare provider for personalized dosage recommendations.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eDirections:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eTake the medication at the same time every day to maintain a consistent level in your body.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eDo not skip doses or discontinue use without consulting your healthcare provider, as this can lead to drug resistance and treatment failure.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eIf you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular schedule.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eCautions:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003ePregnancy and Breastfeeding\u003c\/strong\u003e: Safety during pregnancy has not been established. Women of childbearing age should use effective contraception during treatment. If using with ribavirin, avoid pregnancy due to the high risk of birth defects.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Interactions\u003c\/strong\u003e: Sofosbuvir and Ledipasvir can interact with \u003cstrong\u003eantacids, rifampin, St. John’s Wort, and certain anticonvulsants\u003c\/strong\u003e. Always inform your healthcare provider about all medications and supplements you are taking.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eLiver and Kidney Function\u003c\/strong\u003e: Regular liver and kidney function tests are recommended during treatment.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAvoid Amiodarone\u003c\/strong\u003e: This combination can cause serious bradycardia (slow heart rate) when used with amiodarone.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eManaging Side Effects:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCommon Side Effects\u003c\/strong\u003e: Headache, fatigue, nausea, and insomnia.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSevere Side Effects\u003c\/strong\u003e: Signs of liver problems (yellowing of the skin or eyes, dark urine), chest pain, or severe shortness of breath. Seek immediate medical attention if these symptoms occur.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eManagement Tips\u003c\/strong\u003e: For mild side effects, drink plenty of water, get adequate rest, and take over-the-counter medications like acetaminophen (as advised by your healthcare provider). If side effects persist or worsen, contact your doctor.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eGuidelines:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eComplete the full course of treatment, even if you start feeling better before finishing the medication.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eAvoid alcohol, as it can increase the risk of liver damage.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eRegular blood tests are necessary to monitor the effectiveness of treatment.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eKeep a consistent routine and adhere to your dosing schedule.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003eFrequently Asked Questions (FAQs)\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003col\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat is Sofosbuvir and Ledipasvir used for?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eThis combination is used to treat chronic Hepatitis C infection, particularly genotypes 1, 4, 5, and 6, in adults and certain pediatric patients.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan Sofosbuvir and Ledipasvir cure Hepatitis C?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eYes, Sofosbuvir and Ledipasvir can achieve a sustained virologic response (SVR), which is considered a \"functional cure\" for Hepatitis C when taken as directed.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat are the common side effects of Sofosbuvir and Ledipasvir?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eThe most common side effects include headache, fatigue, and nausea. These symptoms are usually mild and improve over time.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eHow long is the treatment duration?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eThe standard treatment duration is 12 weeks, but this may vary depending on the severity of the disease and the presence of cirrhosis.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan I take Sofosbuvir and Ledipasvir with antacids?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eAntacids can reduce the absorption of Ledipasvir, so take antacids at least 4 hours before or after taking Sofosbuvir and Ledipasvir.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eIs Sofosbuvir and Ledipasvir safe during pregnancy?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eThe safety of this combination in pregnancy has not been established. Women should avoid becoming pregnant during treatment, especially if taken with ribavirin.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat should I do if I miss a dose?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eIf you miss a dose, take it as soon as you remember. If it is close to the time for the next dose, skip the missed dose and continue your regular dosing schedule.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan I drink alcohol while taking Sofosbuvir and Ledipasvir?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eAvoid alcohol while taking this medication, as it can increase the risk of liver damage and affect treatment outcomes.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ol\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eQuick Links\u003c\/strong\u003e:\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca target=\"_new\" rel=\"noopener\"\u003eUnderstanding Sofosbuvir and Ledipasvir Mechanism\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/sofosbuvir-ledipasvir-oral-route\/dosage\/drg-20374643\" target=\"_new\" rel=\"noopener\"\u003eDosage Recommendations for Hepatitis C Treatment\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca target=\"_new\" rel=\"noopener\"\u003eManaging Side Effects of Hepatitis C Medications\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca target=\"_new\" rel=\"noopener\"\u003eDrug Interactions with Sofosbuvir and Ledipasvir\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5500068\/\" target=\"_new\" rel=\"noopener\"\u003eSofosbuvir and Ledipasvir in Pregnancy\u003c\/a\u003e\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e","brand":"EZ Chemist","offers":[{"title":"Default Title","offer_id":51736348885275,"sku":"Hepcvir (Ledipasvir and Sofosbuvir) 90\/400mg-1","price":614.4,"currency_code":"USD","in_stock":true}],"url":"https:\/\/ezchemist.com\/products\/ledipasvir-and-sofosbuvir-harvoni-90-400mg-28-tablets","provider":"EZ Chemist","version":"1.0","type":"link"}