{"product_id":"kombiglyze-xr-saxagliptin-and-metformin-5mg-500mg-28-tablets","title":"Kombiglyze XR (Saxagliptin and Metformin) 5mg\/500mg 28 Tablets","description":"\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eKombiglyze XR Medicine Description\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDrug Class:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eAntidiabetic Combination Drug\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eDipeptidyl Peptidase-4 (DPP-4) Inhibitor \u0026amp; Biguanide\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCategories:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eOral Hypoglycemics\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eDiabetes Treatment\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eActive Ingredient Name:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eSaxagliptin (DPP-4 Inhibitor)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eMetformin (Biguanide)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003ePopular and Other Names:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eKombiglyze XR\u003c\/strong\u003e (brand name)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSaxagliptin\/Metformin XR\u003c\/strong\u003e (generic name)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eOnglyza\u003c\/strong\u003e (Saxagliptin alone)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eGlucophage\u003c\/strong\u003e (Metformin alone)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eMode of Action\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003eKombiglyze XR is a combination medication designed to control blood sugar levels in individuals with type 2 diabetes. The \u003cstrong\u003eSaxagliptin\u003c\/strong\u003e component works by inhibiting the enzyme DPP-4, which increases the levels of incretin hormones that stimulate insulin release in response to meals. The \u003cstrong\u003eMetformin\u003c\/strong\u003e component decreases glucose production in the liver and improves insulin sensitivity. Together, these mechanisms help reduce elevated blood sugar levels effectively.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eHow to Use Kombiglyze XR\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAdministration:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eTake Kombiglyze XR once daily, with the evening meal, to minimize stomach upset. The extended-release (XR) formulation allows for slow and consistent release of the active ingredients throughout the day.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSwallow Whole:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eDo not crush, chew, or split the tablet, as this will interfere with the extended-release mechanism.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eRecommended Dosage\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eInitial Dose:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eFor patients not already taking Metformin, the usual starting dose is 5 mg\/500 mg of Saxagliptin\/Metformin XR once daily.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAdjustments:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eYour doctor may adjust the dosage based on your blood sugar levels, with a maximum daily dose of 5 mg Saxagliptin and 2000 mg Metformin.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eMissed Dose:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eIf you miss a dose, take it as soon as you remember unless it’s almost time for the next dose. Never double the dose.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eTiming:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eTake with food, ideally with dinner, to minimize gastrointestinal side effects from Metformin.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eStore at room temperature in a dry place, away from direct sunlight and moisture.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAvoid Alcohol:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eExcessive alcohol can increase the risk of lactic acidosis, a serious side effect of Metformin.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCautions\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eKidney Function:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eKombiglyze XR should not be used in patients with severe kidney impairment, as Metformin can cause lactic acidosis in such individuals.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eLiver Problems:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eAvoid use if you have liver disease, as it can exacerbate side effects and affect the metabolism of Metformin.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eHypoglycemia Risk:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eAlthough Kombiglyze XR has a low risk of causing hypoglycemia (low blood sugar), caution should be taken, especially when combined with insulin or sulfonylureas.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003ePregnancy \u0026amp; Breastfeeding:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eConsult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking Kombiglyze XR.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eManaging Side Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eGastrointestinal issues\u003c\/strong\u003e (nausea, diarrhea, abdominal discomfort) – usually related to Metformin.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eUpper respiratory infections\u003c\/strong\u003e (common cold, sore throat) – related to Saxagliptin.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eManagement:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eFor gastrointestinal issues, take the medication with food and consider smaller, frequent meals.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003eDrink plenty of water and engage in light physical activity to manage discomfort.\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eLactic Acidosis\u003c\/strong\u003e (symptoms include muscle pain, weakness, trouble breathing, and irregular heartbeat)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003cli\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eSevere allergic reactions\u003c\/strong\u003e (rash, swelling, difficulty breathing)\u003c\/span\u003e\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAction:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eIf you experience symptoms of lactic acidosis or an allergic reaction, stop taking the medication and seek immediate medical help.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eGuidelines\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003cul\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eBlood Sugar Monitoring:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eRegularly monitor your blood sugar levels and consult your doctor for dose adjustments based on your control and response to treatment.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003ePhysical Activity:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eCombine Kombiglyze XR treatment with exercise and a balanced diet to improve blood sugar control.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eAvoid Dehydration:\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eDrink plenty of fluids, especially if engaging in strenuous physical activity or exposure to hot weather, as dehydration can increase the risk of kidney problems.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ul\u003e\r\n\u003chr\u003e\r\n\u003ch3\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eFrequently Asked Questions (FAQs)\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\r\n\u003col\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat is Kombiglyze XR used for?\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eKombiglyze XR is used to control blood sugar levels in individuals with type 2 diabetes, particularly when other oral medications have not been sufficient.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan I take Kombiglyze XR with other diabetes medications?\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eYes, Kombiglyze XR can be combined with other antidiabetic medications like insulin or sulfonylureas, but under careful supervision to avoid hypoglycemia.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eHow long should I take Kombiglyze XR?\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eKombiglyze XR is typically taken long-term to maintain blood sugar control. Your doctor will determine the duration of therapy based on your response.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eCan I take Kombiglyze XR if I have kidney problems?\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eKombiglyze XR is not recommended for patients with severe kidney impairment. Your doctor may perform regular kidney function tests to ensure safety.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eWhat should I do if I experience side effects?\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eIf you experience mild side effects like gastrointestinal discomfort, try taking the medication with food. For severe reactions like lactic acidosis, seek medical attention immediately.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003cli\u003e\r\n\u003cp\u003e\u003cspan style=\"font-size: 18px;\"\u003e\u003cstrong\u003eIs Kombiglyze XR safe during pregnancy?\u003c\/strong\u003e\u003c\/span\u003e\u003cbr\u003e\u003cspan style=\"font-size: 18px;\"\u003eAlways consult your doctor before taking Kombiglyze XR during pregnancy, as controlling blood sugar during pregnancy is essential but requires a personalized approach.\u003c\/span\u003e\u003c\/p\u003e\r\n\u003c\/li\u003e\r\n\u003c\/ol\u003e","brand":"EZ Chemist","offers":[{"title":"Default Title","offer_id":51735734845723,"sku":"Kombiglyze XR (Saxagliptin and Metformin) 5mg\/500mg 28 Tablets","price":59.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0992\/3303\/8619\/files\/kombiglyze_xr_5_500mg_tablet_7_s_0.jpg?v=1770408009","url":"https:\/\/ezchemist.com\/products\/kombiglyze-xr-saxagliptin-and-metformin-5mg-500mg-28-tablets","provider":"EZ Chemist","version":"1.0","type":"link"}